SFI 2013

Welcome coffee

Salon AdenauerANRS
PLENARY SESSION: Infection Immunity

Chairs: Ali Amara (Paris) and Julie Déchanet-Merville (Bordeaux)

Christian Münz (Zürich, Switzerland): Human innate immune responses against viral infections in vivo

Caroline Demangel (Paris, France): Mycobacterium ulcerans-induced immunosuppression

Morgane Bomsel (Paris, France): Vaccine inducing Mucosal antibodies targeting gp41 for blocking mucosal entry of HIV-1: From preclinical studies to Phase I ‘‘Proof of Principle’’

François Trottein (Lille, France): Mode of activation and role of lipid-reactive natural killer T cells during infection

Salon Honnorat & GaleriesCoffee break - Visit of exhibition - Poster session

PARALLEL WORKSHOPS

Salon AdenauerB cell responses

Chairs: Nicolas Fazilleau (Toulouse) and
Bernardo Reina-San-Martin (Strasbourg)

Nicolas Fazilleau: Follicular Helper T cells: Cognate regulators of B cell Immunity

Bernardo Reina-San-Martin: The cohesin complex regulates immunoglobulin class switch recombination

Selected short oral presentations

Christophe Jamin (Brest, France): Differentiation and function of Follicular Helper T cells are regulated by the B lymphocytes

Fanny Lafouresse (Toulouse, France): In Vivo Imaging of B-cell Chronic Lymphocytic Leukemia Extravasation through High Endothelial Venules in Lymph Nodes

Ludovic Moro-Sibilot (Lyon, France): The liver: an underestimated effector site of the intestinal Immunoglobulin A response?

Dorian Obino (Paris, France): Galectin-8 promotes efficient antigen processing and presentation by B lymphocytes

Dania Zhivaki (Paris, France): Human innate-like B cells with regulatory properties in response to viruses

Salon GulbenkianImmunology of Transplantation

Chairs: Sophie Brouard (Nantes) and Gérard Socié (Paris)

Sophie Brouard: The role of B cells in operational tolerance in transplantation

Gérard Socié: Current issues in the pathophysiology of GvHD

Selected short oral presentations

Aude Burlion (Paris, France): Immunotherapy of xeno-Graft vs Host Disease with anti-ICOS monoclonal antibody

Cyril Fauriat (Marseille, France): Reconstitution of Natural Killer Cells In HLA-Matched Stem Cell Transplantation With Peripheral Stem Cells After Reduced Intensity Conditioning

Julien Lion (Paris, France): Endothelial cell allogenicity is increased by HLA class II antibody induced signaling

Lars Rogge (Paris, France): Multi-parameter single-cell profiling of human CD4+FOXP3+ regulatory T cell populations in homeostatic conditions and during graft-versus-host disease

Salon David-WeillNeutrophils & Mast cells

Chairs: Véronique Witko-Sarsat (Paris) and Béhazine Combadière (Paris)

Véronique Witko-Sarsat: Deciphering the cytosolic PCNA scaffold in neutrophils: a new way to control their survival and a potential target to dampen inflammation

Béhazine Combadière: Role of neutrophils in the immunological mechanisms involved after epidermal and dermal immunization

Selected short oral presentations

Julien Diana (Paris, France): Macrophages and beta cells are guilty for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes

Marie-Alix Espinasse (Châtenay-Malabry, France): The anti-inflammatory Glucocorticoid-induced leucine zipper (GILZ) protein is expressed in neutrophils from ARDS patients

Caitlin Gillis (Paris, France): A new technique for specific depletion of neutrophils provides further evidence for their contribution to models of antibody-dependant inflammatory and allergic reactions

Arnaud Millet (Paris, France): Proteinase 3, the target of anti-neutrophil cytoplasmic antibody (ANCA) in vasculitis modifies the macrophage microenvironment after efferocytosis resulting in an activation of plasmacytoid dendritic cells and specific T-cell polarization

Maison de la BelgiqueLunch

Maison InternationaleVisit of exhibition - Poster session

Salon AdenauerBD BIOSCIENCE
PLENARY SESSION: Immune regulation

Chairs: Chairs: Olivier Boyer (Rouen) and Benoit Salomon (Paris)

Bruno Silva-Santos (Lisbon, Portugal): Molecular mechanisms of differentiation of immunoregulatory T cell subsets

Onur Boyman (Zürich, Switzerland): Cytokine-based regulation of immune responses

Agnès Lehuen (Paris, France): Protective and deleterious role of innate immune cells in type 1 diabetes

Naomi Taylor (Montpellier, France): Promoting regulatory T cell differentiation by manipulation of the nutrient environment

Salon Honnorat & GaleriesCoffee break - Visit of exhibition - Poster session

PARALLEL WORKSHOPS

Salon Adenauer Immunity to Pathogens

Chairs: Olivier Lantz (Paris) and Nicolas Blanchard (Toulouse)

Olivier Lantz: Innate like T cells are evolutionarily conserved subsets that recognize non-peptidic antigens originating from bacteria

Nicolas Blanchard: T cell detection of pathogen intrusion: ‘classical’ MHC class I presentation to ‘adaptive’ T cells

Selected short oral presentations

Asma Beldi-Ferchiou (Paris, France): Expression of PD-1 defines a population of highly dysfunctional NK cells with elevated frequency in chronic viral infections

Antonio Peixoto (Toulouse, France): LFA1 acts as gatekeeper of CD8 T cell exhaustion and survival necessary for controlling LCMV infection

Nuno Miguel Ribeiro-Palha (Paris, France): Whole-body imaging of Chikungunya Virus infection and host immune responses

Vasco Rodrigues (Paris, France): Abortive  T  follicular  helper  development  is  associated  with  defective  humoral response in Leishmania infantum-infected macaques

Biljana Zafirova (Paris, France): Selective production of type I IFNs by plasmacytoid DCs activates NK cells and is sufficient to control MCMV infection

Salon Gulbenkian Vaccination

Chairs: Claude Leclerc (Paris) and Danila Valmori (Nantes)

Claude Leclerc: Anti-tumor therapeutic vaccination using Th17-promoting adjuvants reveals potentially detrimental role of IL 17 in anti-tumor immunity

Danila Valmori: CD4 T effector and regulatory subsets in human cancer: implications for the development of vaccines

Selected short oral presentations

Cécile Alanio (Paris, France): Decreased threshold for TCR activation in naive CD8 T cells during HCV chronic infection

Gilles Dadaglio (Paris, France): Antigen targeting to CD11b+ DC in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

Anna Lissina (Paris, France): Dendritic cells Ferchioud using GM‐CSF/IL‐4 or FLT3L respond differently to TLR ligand maturation signals, affecting the quality of the primed CD8+ T‐cell response

Biliana Todorova (Fontenay-aux-Roses, France): Imaging innate immune response in non human primates after DNA vaccination against HIV

Salon David-WeillMechanisms of tolerance

Chairs: Bertrand Dubois (Lyon) and Lucienne Chatenoud (Paris)

Bertrand Dubois: Critical role of epidermal Langerhans cells in both the induction and breakdown of cutaneous tolerance to weak contact allergens

Lucienne Chatenoud: Immune tolerance induction in primed hosts

Selected short oral presentations

Pascal Chappert (Paris, France): Specific gut commensal flora locally alters T cell tuning to endogenous ligands

Tristan Courau (Paris, France): Co-silencing of VEGF and TGFβ in B16 melanoma cells leads to altered Tregs recruitment, modifications of the tumor microenvironment and tumor rejection

Matthieu Giraud (Paris, France): The Hnrnpl processing factor cooperates with Aire to promote transcriptional elongation and ectopic expression of autoantigen genes in the thymus

Natalia Korneychuk (Paris, France): Role of CD8+T cells in a mouse model of enteropathy induced by a dietary antigen

Julien Marie (Lyon, France): TGF-β Signaling in T Cells Controls TCR Activation Threshold

Salon AdenauerBD Biosciences - Thesis Award
SFI - Poster Prizes & Presentation Awards

Meeting closure