SFI 2013

Welcome coffee

Salon AdenauerSANOFI PASTEUR
PLENARY SESSION: Innate Sensing

Chairs: Anne Hosmalin (Paris) and Bertrand Dubois (Lyon)

Steffen Jung (Rehovot, Israël): Probing Mononuclear Phagocytes in Gut and Brain

Ivo Gomperts Boneca (Paris, France): Studying the peptidoglycan in vivo: a microbial determinant modulating the innate host response

Nicolas Manel (Paris, France): Innate Sensing of HIV-1 and HIV-2 by dendritic cells

Isabelle Schwartz-Cornil (Jouy-en-Josas, France): Dendritic subsets across warm blooded vertebrates: from phylogenomic studies to clinical applications

Salon Honnorat & GaleriesCoffee break - Visit of exhibition - Poster session

PARALLEL WORKSHOPS

Salon David-WeillStromal cells

Chairs: Lucie Peduto (Paris) and Marc Bajénoff (Marseille)

Lucie Peduto: Lineage tracing of ADAM12+ stromal cells reveals a dominant
pro-fibrotic pathway in acute injury

Marc Bajénoff: Dynamics of follicular dendritic cells

Selected short oral presentations

Thibaud André (Brussels, Belgium): Immune impairments of the multiple myeloma bone-marrow mesenchymal stromal cells

Mohamed El Behi (Paris, France): Two complementary strategies developed by a variant of bladder tumor to achieve invasiveness: immune escape and decorin secretion

Bertrand Montpellier (Toronto, Canada): A Novel Role for IL7 in Cross-talk Signaling during Medullary Thymic Epithelial Cell Development

Rosalie Ponte (Paris, France): Local Il-7 production participates to cell migrations to the gut of acutely SIV-infected rhesus macaques

Salon GulbenkianGenetics of Immunity

Chairs: Frédéric Rieux-Laucat (Paris) and
Anavaj Sakuntabhai (Paris)

Frédéric Rieux-Laucat: Genetic bases of Primary Immunodeficiencies accompanied with autoimmune manifestations

Anavaj Sakuntabhai: Genetic susceptibility to dengue infection

Selected short oral presentations

Isabelle André-Schmutz (Paris, France): A new form of global leucopenia associated with mutation in the moesin gene

Laura Israel (Paris, France): A new inherited disorder in human : TIRAP deficiency

Fanny Lanternier (Paris, France): Invasive fungal infections and CARD9 deficiency

Lars Rogge (Paris, France): Combinatorial control of Th17 and Th1 cell function by genetic variation at genes associated with the IL-23 signaling pathway in spondyloarthritis

Salon AdenauerDendritic cells, Monocytes & Macrophages
CFCD-SFI session

Chairs: Vassili Soumelis (Paris) and Marc Dalod (Marseille)

Vassili Soumelis: Environmental control of human dendritic cell diversity

Marc Dalod: Are primate XCR1+ DC worth targeting for immunotherapy: hope or hype?

Selected short oral presentations

Mehdi Ellouze (Créteil, France): Increasing GILZ in macrophages regulates their inflammatory responses in vivo and enhances survival in septic shock

Agnès Le Bon (Paris, France): Chronic exposure to IFNα promotes suppressor monocytes: Consequences on subsequent immune response

Aymeric Silvin (Paris, France): Confinement of HIV innate immune sensing and replication within blood dendritic cell subsets

Pablo Vargas (Paris, France): Developmental Regulation of actin nucleation and dendritic cell migration by Arp2/3 and mDia1

Maison de la BelgiqueLunch

Maison InternationaleVisit of exhibition - Poster session

Salon GulbenkianSESSION: Women in Immunology

Chairs: Danila Valmori (Nantes) and Anne Hosmalin (Paris)

Danila Valmori (SFI): Introduction

Anne Pépin (CNRS): The Mission for Women at the CNRS

Catherine Fridman (EFIS): Female representation at major immunology congresses : work still to be done

Anne Hosmalin (SFI): The French Society for Immunology (SFI) takes action

Round table

Chair: Armelle Regnault (Immunology Hematology Pneumology Institute, Aviesan)

Salon AdenauerLA LIGUE CONTRE LE CANCER
PLENARY SESSION: Tumor Immunity

Chairs: Matthew Albert (Paris) and Jérôme Galon (Paris)

Catherine Wu (Boston, USA): From ELISpot to bedside: Developing a personalized neoantigen cancer vaccine

Thomas Blankenstein (Berlin, Germany): Spontaneous and therapy-induced T cell responses to cancer

Hy Levitsky (Schlieren, Switzerland): Realizing the Promise of Cancer Immunotherapy

Eric Tartour (Paris, France): Mucosal imprinting of vaccine induced-CD8+T cells is crucial to inhibit mucosal tumors

Salon Honnorat & GaleriesCoffee break - Visit of exhibition - Poster session

PARALLEL WORKSHOPS

Salon David-WeillTherapeutics in Immunology

Chairs: Pierre Bruhns (Paris) and Jean-Luc Teillaud (Paris)

Pierre Bruhns: Role of IgG receptors and neutrophils in experimental mAb-induced cancer therapy

Jean-Luc Teillaud: Emerging challenges in monoclonal antibody therapeutics: from new formats and optimized Fc structures to biosimilars

Selected short oral presentations

Neila Chekkat (Illkirch, France): Development of peptidic ligands to target TRAIL-R2 receptor: potential application in cancer therapy

Sophie Conchon (Nantes, France): Liver cancer immunotherapy with agonistic anti-CD137 (4-1BB) antibody

Claire Deligne (Paris, France): Deciphering adaptive anti-tumor immunity induced by anti-CD20 mab treatment: anti-CD20 therapy induces a memory Th1 response through an IFN-gamma/IL-12 axis and opposes Treg-mediated tumor facilitation

Fabricio Montalvão (Paris, France): The Mechanism of Anti-CD20-Mediated B cell Depletion Revealed by Intravital Imaging

Salon GulbenkianLymphocyte development & selection

Chairs: Ana Cumano (Paris) and Marie Malissen (Marseille)

Ana Cumano: Two waves of distinct hematopoietic progenitors colonize the fetal thymus

Marie Malissen: Rltpr, a lymphoid-specific protein essential for CD28 costimulation and regulatory T cell development

Selected short oral presentations

Claire Berthault (Paris, Farnce): Molecular regulation of lymphoid commitment in the murine fetal liver Common Lymphoid Progenitor (CLP)

Cyrille Ramond (Paris, France): Characterization of the fetal thymic settling progenitors

Nicolas Thiault (Toulouse, France): Recirculation of peripheral cells influences the phenotype and TCR-repertoire of thymic regulatory T lymphocytes

Melanie Wencker (London, UK): Innate-like T cells straddle innate and adaptive immunity by revising antigen-receptor responsiveness

Salon AdenauerAutoimmunity

Chairs: Luc Mouthon (Paris) and Eliane Piaggio (Paris)

Luc Mouthon: Autoimmune diseases: abnormal autoimmune reaction and/or defective control mechanisms?

Eliane Piaggio: Potential and limitations of IL-2 and rapamycin as immunosuppressors

Selected short oral presentations

Cécile Contin-Bordes (Bordeaux, France): OX40L alters regulatory and follicular helper T cell responses in human Systemic Lupus Erythematosus

Lucile Garidou (Toulouse France): The Dowregulation of Intestinal RORgt-induced Th17 lymphocytes is responsible for the Onset of Type 2 Diabetes in the mouse

François-Xavier Mauvais (Paris, France): Multiplex Single-Cell Analysis of CD8+ T Lymphocytes Populations in Recent-Onset human Type 1 Diabetes Identifies a Specific Molecular Signature Associated with the Juvenile Form of the Disease

Mark McCarron (Lyon, France): TGFbeta regulates unrestrained T follicular helper cell expansion and prevents loss of B cell tolerance

Sothea Touch (Paris, France): Perturbed innate and adaptive immunity in human obese intestine: impact on intestinal insulin sensitivity

Salon GulbenkianASSIM General Assembly