SFI-AFC 2014

PLENARY SESSION: Inflammation

Pasteur - Level 8

Chairs: Maria Leite de Moraes - Paris (FR) and François Trottein - Lille (FR)

Isabelle Maridonneau-Parini - Toulouse (FR): Mechanisms of macrophage tissue infiltration

Pierre Desreumaux - Lille (FR): From physiopathology to new therapeutic strategies in IBD

Delphine Boche - Southampton (UK): Is inflammation a key element of Alzheimer’s disease?

Pierre Bruhns - Paris (FR): Roles of Neutrophils in Antibody-induced Inflammation

SESSION PLÉNIÈRE : Forum Technicien

Eurotop - Level 5

Modérateurs : Nicolas Bailly - Yvoir (BE) et Jacques Trauet - Lille (FR)

Nicolas Bailly : La quantification cellulaire absolue en cytométrie en flux : pièges et limites

Jacques Trauet : Comment optimiser le tri par cytométrie en flux ?

Communications orales courtes sélectionnées

Julie Demaret - Lyon (FR): Comparative dose-responses of STAT5 phosphorylation to recombinant human IL-2 and IL-7 in CD4+FOXP3- cells versus regulatory T cells: A whole-blood perspective

Michelle Yap - Nantes (FR): Comprehensive study of 3 nomenclatures to discriminate CD8 subsets in healthy volunteers and in kidney transplant recipients

Angeline Rouers - Paris (FR): Multiple defective follicular helper T cells subsets support inappropriate germinal center reaction in chronic HIV infection

Allergic diseases

Rubens - Level 9

Anne Tsicopoulos - Lille (FR): NOD2-mediated exacerbation of allergen-induced asthma modifies IL-17 and IL-22 profiles

Christophe Desmet - Liège (BE): Mechanisms of induction of allergen-specific auxiliary T cell responses by lung dendritic cells

Selected short oral presentations

Fabienne Andris - Gosselies (BE): Antigen Presenting Cell-derived Interleukin-6 Restricts Th2 Responses

Isabelle Gengler - Lille (FR): Identification of factors of hypereosinophilia during nasal polyposis. Combined role of interleukin-5 and interleukin-9 in asthmatic patients

Maxime Durand - Nantes (FR): A regulatory CD9⁺ B cell subset controls HDM-induced allergic airway inflammation

Immune Therapies

Session organized by CRI   

Pasteur - Level 8

Benjamin Terrier - Paris (FR): New biological and therapeutic strategies in the treatment of ANCA-associated vasculitides

Isabelle Koné-Paut - Le Kremlin-Bicêtre (FR): Biological strategies to overcome autoinflammatory diseases

Selected short oral presentations

Aude Burlion - Paris (FR): A novel anti-human ICOS antibody to cure graft versus host disease without weakening graft versus leukemia potential

Sandro Silva Gomes - Toulouse (FR): Mannodendrimers attenuate LPS-induced dendritic cell maturation and prevent acute lung inflammation via C-type lectin SIGNR1

Guillaume Brachet - Tours (FR): Therapeutic drug monitoring of eculizumab: basis for an individualized schedule

Quentin Khebizi - Evry (FR): Anterior Chamber Associated Immune Deviation (ACAID): A new mechanism to inhibit specifically anti-transgene cellular immune responses in the context of systemic gene transfer?

Small RNAs and Transcriptomics

Eurotop - Level 5

Lionel Navarro - Paris (FR): Small RNA-directed control of the host innate immune response and its targeting by bacterial effectors

Almudena Ramiro - Madrid (SP): MicroRNAs link the germinal center reaction with mature B cell lymphomagenesis

Selected short oral presentations

Yasmina Serroukh - Gosselies (BE): Human cytotoxic CD4 T cells express a CD8 T cell lineage transcriptional program

Romain Loyon - Besançon (FR): Interleukin 21-induced MHC class II⁺ CD86⁺ NK cells promote the expansion of human uncommitted CD4⁺ central memory T lymphocytes

Alexis Régent - Paris (FR): Proteomic and genomic analysis of vascular smooth muscle cells from patients with giant cell arteritis

Nicolas Bidère - Paris (FR): A role for the LUBAC in antigen receptor-mediated NF-KB activation and in lymphoma survival

Biologie Végétale et Océanographie

Goya - Level 9

Modérateur : Mickael Bourge - Gif-sur-Yvette (FR)

Danny Geelen - Gand (BE) : Measurement of pollen size variation and ploidy determination

Sergio Ochatt - Dijon (FR) : Contribution de la cytométrie en flux à la taxonomie, la biologie du développement et la physiologie du stress chez les plantes

Communications orales courtes sélectionnées

Sarah Fiorini - St Pierre-lès-Nemours (FR) : La cytométrie en flux appliquée à la recherche en écologie aquatique : une vue d’ensemble

Abdellah Benabdelmouna - Ronce-les-bains (FR) : Caractérisation de la qualité cytogénétique des huîtres creuses (Crassostrea gigas) par cytométrie en flux : relation avec les crises de surmortalité

Coffee - Visit of exhibition - Poster session

Espace Flandre - Level 8

Chairs: Sylvia Cohen-Kaminsky - Le Plessis-Robinson (FR) and Anne Hosmalin - Paris (FR)

Christiane Durieux - Paris (FR): Current status of women at Inserm

Ingrid Bianchi - Boulogne Billancourt (FR): Breaking the Glass Ceiling

Immune system ontogeny and Aging

Pasteur - Level 8

Stanislas Goriely - Brussels (BE): Innate immunity at the extremes of age, a focus on IL-12 and related cytokines

Delphine Sauce - Paris (FR): Impact of herpes virus infections on immune aging

Selected short oral presentations

Leslie Hesnard - Nantes (FR): Impact of the MHC-restricting allele expression on the human Ag-specific thymic T cell repertoire

Maria Leite-de-Moraes - Paris (FR): TLR-induced cytokines promote effective pro-inflammatory Natural T-helper 17 cell responses

Arnaud Köhler - Gosselies (BE): Functionality of pre-DNGR1⁺CD8α⁺ dendritic cells in early life

Catalina Lee-Chang - Baltimore (US): A novel aging-associated B-cell subset controls antitumor CD8+ T-cell response

Chronic Infections

Rubens - Level 9

Olivier Neyrolles - Toulouse (FR): B cells modulate inflammation during Mycobacterium tuberculosis infection in a MyD88- and type I interferon-dependent manner

Isabelle Chemin - Lyon (FR): Hepatitis B chronic infections: A still overlook entity

Selected short oral presentations

Florent Carrette - San Diego (US): CD44 controls T cell exhaustion and viral persistence during chronic viral infection

Eric Champagne - Toulouse (FR): Alteration of gamma delta subsets in solid organ transplanted patients at the acute phase of hepatitis E virus infection

Laetitia Petit-Jentreau - Paris (FR): Purinergic pathway affects the response of human macrophages infected with Mycobacterium tuberculosis

Mireille Laforge - Paris (FR): An anti-apoptotic drug prevents disease progression in SIV-infected rhesus macaques

Inflammatory Bowel Diseases

Eurotop - Level 5

Kevin Maloy - Oxford (UK): Innate immune sensors in protection and pathology in the intestine

Laurent Peyrin-Biroulet - Nancy (FR): Adhesion molecules: the best target in inflammatory bowel disease?

Selected short oral presentations

Anne Jarry - Nantes (FR): Evidence for the differential subordination of the IL-18 / IFN-gamma axis to caspase-1 among patients with Crohn’s disease

Laura Choteau - Lille (FR): Role of Mannose Binding Lectin in intestinal homeostasis and pathogen

Lidia Ibañez - Nice (FR): Murine osteoclasts derived from dendritic cells induce TNFα-producing CD4+ T cells in inflammatory bowel disease

Zhe Li - Leuven (BE): Prediction of Clinical Response to Anti-TNF Therapy for Inflammatory Bowel Diseases by Circulating Foxp3(+) and Foxp3(-) regulatory T cell Subsets but not by B Cells

Hématologie 2

Artois - level 5

Modérateurs : Bernard Chatelain - Yvoir (BE) et Francine Garnache-Ottou - Besançon (FR)

Romarick Lacroix - Marseille (FR) : Microparticle enumeration and standardization by flow cytometry

Jean Feuillard - Limoges (FR) : Phénotype des PNN dans le sepsis

Christophe Ginestier - Marseille (FR) : Détection des cellules cancéreuses par cytométrie en flux

Communications orales courtes sélectionnées

Isabelle Arnoux - Marseille (FR) : Intérêt de la maladie résiduelle, à J15 dans le sang, par cytomètrie en flux, au cours des leucémies lymphoblastiques B : Mesure de la réponse précoce au traitement

Véronique Latger-Cannard - Vandoeuvre-les-Nancy (FR) : Optimisation de la détection des cellules métastatiques médullaires de neuroblastome par cytométrie en flux multiparamétrique

Stephan Frédéric - La Louvière (BE) : Etude de l’expression du CD180 et du CD200 dans la classification des néoplasies des lymphocytes B en cytométrie en flux

Chair: Anne Hosmalin - Paris (FR)

Sebastian Amigorena - Paris (FR): The histone-H3 methyltransferase Suv39h1 is required for CD8+ T cell heterochromatin organization and clonal expansion

PLENARY SESSION: Metabolism and Immunity

Salle Pasteur - Level 8

Chairs: Isabelle Wolowczuk - Lille (FR) and Oberdan Leo - Brussels (BE)

Anthony W. Ferrante - New-York (US): Immune regulation of adipose tissue function and mass

François Leulier - Lyon (FR): Host/Microbiota mutualism: learning on the fly

Patrice Cani - Brussels (BE): Targeting intestinal innate immunity controls gut microbes and host metabolism during obesity and type 2 diabetes