SFI-AFC 2014

PLENARY SESSION: Cancer

Pasteur - Level 8

Chairs: Fathia Mami-Chouaib - Paris (FR) and Sylvia Cohen-Kaminsky - Le Plessis-Robinson (FR)

W. Hervé Fridman - Paris (FR): Shaping the immune landscape in human cancer

Muriel Moser - Bruxelles (BE): Role of cyclophosphamide in tumor rejection and tumor-specific immunity

Laurence Zitvogel - Villejuif (FR): Gut microbiota-cancer axis in melanoma

SESSION PLÉNIÈRE : Avancées Technologiques

Eurotop - Level 5

Modérateurs : Vincent Genty - St-Malo (FR) et Christian Muller - Strasbourg (FR)

Ali Talebi - Leuven (BE): CRISPR based gene ‘surgery’ in basic and translational research

Julie Cazareth - Valbonne (FR) et Cédric Aït-Mansour - Puteaux (FR) : L’analyse spectrale en flux : principe et applications

Communications orales courtes sélectionnées

Nathalie Dupas - Marseille (FR) : DuraClone^TM improves standardization of compensation workflow for multicolor applications by flow cytometry

Françoise Gondois-Rey - Marseille (FR) : InfoCyt, une nouvelle méthode d’analyse des données de cytométrie multi-paramétrique basée sur le calcul des populations suivie de leur identification visuelle

Vaccination

Pasteur - Level 8

Behazine Combadière - Paris (FR): Mechanisms of epidermal and intradermal routes of immunization

Jean-Claude Sirard - Lille (FR): Activation of Type 3 Innate Lymphoid Cells in the Lungs During Bacterial Infection

Selected short oral presentations

Mohamed Habbeddine - Marseille (FR): Receptor Activator of NF-kB (RANK) signaling in dendritic cells integrates CD4 T cell help for memory CD8 T cell activation

Martin Larsen - Paris (FR): Pathogen-specific CD4⁺ and CD8⁺ T cell polyfunctionality is a correlate of immune protection

Laetitia Fend - Illkirch-Graffenstaden (FR): Intravenous injection of MVA virus targets CD8⁺ T lymphocytes to tumors to control tumor growth upon combinatorial treatment with a TLR9 agonist

Nadege Bercovici - Paris (FR): Vaccine-induced tumor regression requires the cooperation of macrophages and T cells

Auto-immunity

Rubens - Level 9

Sylvie Guerder - Toulouse (FR): Thymus specific serine protease controls the development of autoreactive CD4 T cells and autoimmunity

Bruno Lucas - Paris (FR): TCR signaling events are required for maintaining regulatory CD4 T-cell numbers and suppressive capacities in the periphery

Selected short oral presentations

Charlotte Pouchy - Paris (FR): Regulatory T cell homeostasis and function are dependent of TNFα receptor 2

Laure Garnier - Toulouse (FR): Cell-intrinsic estrogen receptor α activation in CD4⁺ T cells controls Th1/Th17 differentiation in trans and protects from CNS autoimmunity

Mathieu Andrianne - Gosselies (BE): Tristetraprolin expression by keratinocytes plays a key role in the control of skin inflammation

Sanae Ben Mkaddem - Paris (FR): Amelioration of arthritis through the shifting of FcγRIIA-ITAM from activation to inhibitory configuration

B Lymphocytes

Goya - Level 9

Claudia Mauri - Londres (UK): The composition of microbiota is pivotal in driving the differentiation of regulatory B cells

Marion Espeli - Clamart (FR): Impact of a gain-of-function mutation of CXCR4 on the germinal centre reaction and humoral immunity

Selected short oral presentations

Pierre Milpied - Marseille (FR): Remodeling class-switched memory B cells in secondary germinal centers

Soizic Garaud - Brussels (BE): Characterization and organization of infiltrating B-cells in human breast cancer

Zhe Li - Leuven (BE): Anti-TNF Therapy Restores Peripheral Blood B Cell Subsets and CD40 Expression in Inflammatory Bowel Diseases

Christopher Mueller - Strasbourg (FR): Stromal RANKL regulates B cell follicle formation

Détection d’évènements rares

Eurotop - Level 5

Modérateurs : Thierry Idziorek - Lille (FR) et Jean-François Mayol - Grenoble (FR)

David Smadja - Paris (FR): Cytometry Contribution in circulating endothelial cells detection

Thierry Idziorek - Lille (FR) : Comment “sortir” une aiguille d’une botte de foin ?

Communications orales courtes sélectionnées

Laetitia Gautreau - Nantes (FR) : Une nouvelle approche de production d’anticorps monoclonaux humains spécifiques de complexes peptide/CMH

Karim Helmi - Saint-Maurice (FR): Monitoring of three drinking water treatment plants using flow cytometry

Coffee - Visit of exhibition - Poster session

Espace Flandre - Level 8

AFC General Assembly

Eurotop - Level 5

Lectures by Jacques Oudin Awards Laureates    
and Jacques Oudin Awards Ceremony

Pasteur - Level 8

Chairs: Jean-Luc Teillaud - Paris (FR) and Rémi Urbain - Les Ulis (FR)

Matthew L. Albert - Paris (FR): Mechanistic characterization and clinical applications related to cell death and cross-priming

Jérôme Galon - Paris (FR): Immunoscore in the era of cancer immunotherapies

François Kourilsky Lecture

Pasteur - Level 8

Chair: Sebastian Amigorena - Paris (FR)

Éric Vivier - Marseille (FR): Natural Killers, Innate Lymphoid cells and Innate Immunity

Grabar Conference

Pasteur - Level 8

Chair: Catherine Sautes-Fridman - Paris (FR)

Veejay K. Kuchroo - Boston (US): Transcriptional network controlling development of Tregs and Th17 cells

Microbiologie industrielle

Rubens - Level 9

Modérateurs : Steve Crussard - Lyon (FR) et Marielle Bouix - Thiverval-Grignon (FR)

Marc Lanson - Marcy L’Étoile (FR) : La cytométrie en flux un nouvel outil de caractérisation des gels d’aluminium utilisés comme adjuvant dans les vaccins

Camille Chiron - Montréal (CA): Development of antibodies used with flow cytometry for specific enumeration of probiotics in multi-strain products

Communications orales courtes sélectionnées

Vincent Genty - Saint Malo (FR) : Mise au point d’une méthode de détection des Brettanomyces par immunocytométrie

Aurore Sarazin - Lille (FR) : Influence de la phagocytose sur l’expression de surface des glycanes de Candida albicans

Symposium Alexion   

Eurotop - Level 5

Modérateur : Bernard Drénou - Mulhouse (FR)

Bernard Drénou, Mulhouse (FR) : Présentation des 4 cas de l’échange interlaboratoire

Rémi Letestu, Bobigny (FR): Rappels de la terminologie (limite de détection, sensibilités)

Agathe Debliquis, Mulhouse (FR): Explication des statistiques robustes

Orianne Wagner-Ballon, Créteil (FR): Observatoire du petit clone

Symposium eBioscience   

Genomics meets proteomics using FlowRNA Assay

Eurotop - Level 5

Morgane Griesbeck - Paris (FR): An example of use in: Sex differences in the pDC TLR7/IFNa pathway

Symposium Beckman Coulter   

Eurotop - Level 5

Jacques Vigne - Beckman Coulter France : DuraClone : la solution pour les Etudes Multicentriques en cytométrie multicouleur

Christophe Jamin - Brest (FR) : Stratégie d’implantation et retour d’expérience : Etude Precisads

Olivier Jaen - Beckman Coulter France : Le support d’un spécialiste dans l’élaboration des cocktails

Tolerance

Rubens - Level 9

Sylvaine You - Paris (FR): CD3 antibody-induced tolerance: from autoimmunity to transplantation

Maria-Cristina Cuturi - Nantes (FR): Tolerogenic Dentritic Cells therapy, from animal models to clinical protocol

Selected short oral presentations

Yirajen Vuddamalay - Toulouse (FR): Mouse and human CD8 ⁺ CD28 ^low regulatory T cells differentiate as a separate lineage in the thymus

Valentin Le Guen - Nantes (FR): Liver gene transfer induces tolerance toward allogeneic MHC I molecule

Ludovic Martinet - Toulouse (FR): CD226 identifies an alternative program of differentiation generating two distinct NK cell functional subsets

Claire Lhuillier - Villejuif (FR): Impact of exogenous galectin-9 on human T cells : contribution of the TCR complex to antigen-independent activation but not apoptosis induction

Myeloids Cells

Pasteur - Level 8

Toby Lawrence - Marseille (FR): The Role of IkB Kinase (IKK) in Inflammation and Immunity

Martin Guilliams - Ghent (BE): Role of ILC2s in the induction of alternatively activated macrophages during peripheral nerve injury

Selected short oral presentations

Gregory Gautier - Paris (FR): Mast cells aggravate sepsis in mice by inhibiting peritoneal macrophage phagocytosis

François-Xavier Mauvais - Paris (FR): CD169^high spleen macrophages are efficient antigen presenting cells with unique molecular equipment

Chloé Abels - Elsene (BE): Ly6C- monocytes regulate parasite-induces liver inflammation by inducing the differentiation of pathogenic Ly6C+ monocytes into macrophages

Estelle Devêvre - Paris (FR): Monocytes in human obesity: subsets and functions

Anti-tumor immunity

Eurotop - Level 5

Bruno Quesnel - Lille (FR): Tumor dormancy: long-term survival in a hostile environment

Martin Röcken - Tübingen (DE): Cytokine-induced senescence in cancers and recent success in cancer immunotherapy

Selected short oral presentations

Dhafer Mrizak - Lille (FR): Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

Amelien Sanlaville - Lyon (FR): Epithelial-Mesenchymal Transition in Breast Cancer Carcinoma: an immune evasion mechanism?

Laurent Beziaud - Besançon (FR): Impact of adaptive T cell immunity on the antitumor efficacy of mTOR inhibitors

Sylvain Simon - Nantes (FR): Regulation and fonction of PD-1 on melanoma specific T lymphocytes for use in adoptive cell transfer trials

Priyanka Devi - Paris (FR): Role of tumor-infiltrating regulatory T cells according to the presence of tertiary lymphoid structures

Imagerie

Goya - Level 9

Modérateurs : Julien Picot - Évry (FR) et Christian Slomianny - Lille (FR)

Laurent Groc - Bordeaux (FR): Autoantibodies in brain circuits: uncovering cellular alteration using single nanoparticle imaging

Olivier Français - Cachan (FR) : Apport des microtechnologies pour l’étude des propriétés diélectriques cellulaires : application au tri et à la capture de cellules biologiques en environnement microfluidique

Communications orales courtes sélectionnées

Sébastien Dussurgey - Lyon (FR) : Nouvel outil d’analyse topographique à haut débit de l’intensité de fluorescence sur cellule unique : application en immunologie fondamentale

Corinne Laplace-Builhé - Villejuif (FR) : Développement d’une imagerie multi-échelles et multi-modalités pour caractériser in vivo les tumeurs et le microenvironnement associé