EAVPT 2015

PARALLEL SESSIONS

Antimicrobials 1 & Antibiotic resistance

Room 200

Chairs: T. Simon and M. Everett

Antibiotics and antibiotic resistance in Veterinary Medicine - future challenges
Tony Simon - Zaventem (BE)

Development of antivirulence compounds as replacements or adjuncts to antibiotics in animal health
Martin Everett - Labège (FR)

Short oral communications

Characterization and prevention of fluoroquinolone resistance in Escherichia coli isolated from animals
M. Cengiz - Bursa (TU)

Evaluation of the influence of treatment time and antibiotic dosage regimen on bacterial burden and clinical outcomes in experimentally infected calves with Mannheimia haemolytica
G. Lhermie - Paris (FR)

Pharmacokinetics, pharmacodynamics and local tolerance at injection site of marbofloxacin administered via regional intravenous limb perfusion in standing horses
E. Lallemand - Toulouse (FR)

Pharmacodynamic/pharmacokinetic analysis of cephalexin activity on Staphylococcus aureus in a new in vitro model with and without macrophages
E. Lallemand - Toulouse (FR)

Pharmacokinetics 1

Auditorium 450

Chairs: J. Gabrielsson and A. Anadón

Dose-response-time data analysis: A poorly explored topic in pharmacokinetic and pharmacodynamic practice
Johan Gabrielsson - Upssala (SE)

Short oral communications

Pharmacokinetics of metoclopramide: intravenous, intramuscular, subcutaneous and per rectum administrations in rabbits
V. de Vito - Sassari (IT)

Flupirtine: pharmacokinetics and disposition in the horse
M. Giorgi - Pisa (IT)

Relation between age-dependent change in hemodynamics and metronidazole body clearance in turkeys
M. Switala - Wrocław (PL)

Pharmacokinetics of repeated sodium salicylate administration to laying hens: evidence for time dependent increase in drug elimination from plasma and eggs
B. Poźniak - Wrocław (PL)

Toxicology 1 - Clinical/farm animals & Regulatory

Rooms G-H

Chairs: M. Perez-Lopez and C. Nebbia

Ruminant toxicology diagnosis: How to proceed?
Marcos Perez-Lopez - Caceres (ES)

Short oral communications

Monitoring of milk, chicken meat eggs and feed for GMO’s using PCR based microarray
G. Sarathchandra - Tamilnadu (IN)

ABCG2-pesticide interactions in the bovine mammary gland and pesticide-mediated induction of ABCG2 efflux activity by the arylhydrocarbon receptor
S. Halwachs - Leipzig (GE)

Comparison of the antithrombotic activity of ferulenol and ferprenin, two prenylated coumarins contained in Ferula communis
V. Lattard - Marcy-l’Etoile (FR)

Comparing User Risk Assessment – Veterinary Medicinal Products versus Biocides
D. Pfeifer - Munich (GE)

Antimicrobials 2 & Antibiotic resistance

Room 200

Chairs: J.-Y. Madec and P.-L. Toutain

Methicillin-resistant Staphylococcus pseudintermedius – a problematic issue for companion animals
Jean-Yves Madec - Lyon (FR)

Short oral communications

Fluoroquinolones in vitro dynamic model to minimize emergence of resistant Salmonella enterica serovar Typhimurium
S.-J. Lee - Dae-gu (KS)

Comparative pharmacodynamics of ciprofloxacin, enrofloxacin and norfloxacin for Escherichia coli of diarrheic calves
P. Sidhu - Punjab (IN)

Demonstration of applicability of PK/PD concepts to determine a dosage regimen for tulathromycin in the calf
P.-L. Toutain - Toulouse (FR)

Protocols for the assessment of biofilm formation and sensitivity: Model experiments with Staphylococcus epidermidis
J. Fink-Gremmels - Utrecht (NL)

Pharmacodynamics 1 - General

Auditorium 450

Chairs: J. Elliott and Q. Mc Kellar

From isolated blood vessel to in vivo cardiovascular drug action
Jonathan Elliott - London (UK)

Specificity of pharmacokinetics and pharmacodynamics in old animals
Petra Cagnardi - Milan (IT)

Short oral communications

Developmental-related alteration of the cardiac β-adrenergic system in turkey poults
S. Hoffmann - Leipzig (GE)

Effect of nitric oxide synthase inhibition on blood pressure and nitric oxide concentrations in control and previously laminitic ponies
J. Elliott - London (UK)

First-in-class angiotensin receptor-neprilysin inhibitor LCZ696 markedly influences the dynamics of circulating cGMP and biomarkers of the renin-angiotensin aldosterone system in dogs
J. Mochel - Basel (SZ)

Effects of dexamethasone treatment on B-adrenergic receptors in target organs of veal calves
C. Vercelli - Grugliasco (IT)

Differential Expression of Skeletal Muscle Genes Following Administration of Clenbuterol to Exercised Horses
H. Knych - Davis (US)

Immunomodulatory effects of hyaluronan oligosaccharides in equine peripheral blood mononuclear cells
J. Vendrig - Utrecht (NL)

Drug residues

Rooms G-H

Chairs: T. Whittem and L. Letendre

New approach for modeling drug concentrations in milk and for calculation of withdrawal times
Ted Whittem - Melbourne (AU)

International Methods for Consumer Risk Assessment of Injectable Veterinary Medicines Lack of Harmonization Can Impact International Trade
L. Letendre - Duluth (US)

Short oral communications

Understanding intra-mammary beta-lactam pharmacokinetics using a physiologically-based model
A. Woodward - Werribee (AU)

Monitoring of chloramphenicol residues in milk, chicken meat and eggs lcmsms
G. Sarathchandra - Tamilnadu (IN)

Transcriptomic analysis of skeletal muscle from beef cattle exposed to illicit schedules containing dexamethasone: identification of new candidates and their comparison with proteomics data and samples from field monitoring
R. Elgendy - Legnaro (IT)

Pharmacokinetics and Tissue Residue of Toltrazuril in Broiler Chickens
A. Soliman - Giza (EG)

Bayer Roundtable - Animal Farming & the Need for Innovation in the Mitigation of Infectious Diseases

Room 200

Chairs: P.-L. Toutain and J.-C. Desfontis - Moderator: D. Veerman

Perspectives from the Food Industry
Ignacio Blanco-Traba - Madrid (SP)

Immunomodulation as an approach for reduction of antibiotics - Stimulation of the innate immune response for an enhanced resistance against infections
Armin Saalmüller - Vienna (AU)

Mitigating infectious diseases in farm animals
Johanna Fink-Gremmels - Utrecht (NL)

PK/PD Modeling

Auditorium 450

Chairs: J. Mochel and P. Lees

Chronopharmacology of the renin-angiotensin aldosterone system in dogs: the value of pharmacokinetic/pharmacodynamic modeling
Jonathan Mochel - Basel (SZ)

Short oral communications

PK/PD evaluation of the novel atypical opioid tapentadol in yellow-bellied slider turtles (Trachemys scripta scripta)
M. Giorgi - Pisa (IT)

A PK/PD study in trachemis turtles after single intracoelomic injection of Marbofloxacin at different doses
C. Vercelli - Grugliasco (IT)

Efficacy of florfenicol and gamithromycin in an Ornithobacterium rhinotracheale infection model in turkeys: A pharmacokinetic-pharmacodynamic approach
A. Watteyn - Merelbeke (BE)

Pharmacokinetics and clinical efficacy of meloxicam in Italian Mediterranean Buffalo calf (Bubalus bubalis)
P. Cagnardi - Milano (IT)

Pharmacodynamic and pharmacokinetic (PK/PD) pooled modelling of the antihypertensive response to amlodipine in hypertensive cats
L. Pelligand - Hatfield (UK)

Endocrine Disruptors

Rooms G-H

Chairs: C. Viguié and B. Le Bizec

Endocrine disruptors toxicology: what can domestic species bring to the table?
Catherine Viguié - Toulouse (FR)

Short oral communications

In vitro toxicity of some pesticides on goat and dog spermatozoa
B. Yurdakok Dikmen - Ankara (TU)

Bisphenol A-glucuronide hydrolysis in the ovine fetal compartment prolongs the fetal exposure to Bisphenol A
G. Gauderat - Toulouse (FR)

Evaluation of Antropogenic Ecotoxicity in Ankara River Using RTG2 Cell line
B. Yurdakok Dikmen - Ankara (TU)

Bisphenol A: comparison of the pharmacokinetics profiles obtained after 3 routes of administration
D. Guignard - Toulouse (FR)

Workshop - Pharmacovigilance

Auditorium 450

Chairs: P. Sanders and E. Motschwiller

Perspectives for applied pharmacology in veterinary pharmacovigilance
Cédric Colmar - Fougères (FR)

Pharmacovigilance surveillance over the life cycle of the Product
Edelgard Motschwiller et Corinne Tzanavaris - Paris (FR)

Point of view of pharmacologist about pharmacovigilance surveillance
Michel Laurentie et Pascal Sanders - Fougères (FR)

Short oral communications

Interactions of clay-based feed additives with orally administered veterinary drugs
T. De Mil - Merelbeke (BE)

Trilostane drug safety surveillance: a retrospective study of 103 cases
D. Rochel - Nantes (FR)

Applied biostatistics

Room 200

Chairs: L. Pelligand and R. Servien

Monte Carlo simulations and their application in veterinary medicine
Ludovic Pelligand - Hatfield (UK)

Multivariate analysis of clinical scores: A population PK/PD approach
Remi Servien - Toulouse (FR)

Short oral communications

Effect of furosemide on diuresis and renin-angiotensin aldosterone activation in dogs: a model-based dose-response approach
J. Mochel - Basel (SZ)

Impact of early antimicrobial prevention on broiler flocks performances - a propensity score analysis
C. Chauvin - Ploufragan (FR)

A kinetic of effects study: an attempt to model intracellular mechanisms generated by drug-receptor interaction
C. Thorin - Nantes (FR)

Contaminants

Rooms G-H

Chairs: P. De Backer and B. Le Bizec

Mycotoxins - True natural toxins
Johanna Fink-Gremmels - Utrecht (NL)

Short oral communications

Effects of Deoxynivalenol on intestinal barrier functions: a comparative in vitro/in vivo assessment
S. Braber - Utrecht (NL)

Comparative toxicokinetics, absolute oral bioavailability and biotransformation of zearalenone in different poultry species
M. Devreese - Merelbeke (BE)

Fates and tissue dispositions of deoxynivalenol and zearalenone in broilers
A. Poapolathep - Bangkok (TH)

Stachybotryotoxicosis in cattle - About a case
M. Kammerer - Nantes (FR)