SFI-AFC 2017

Grande Nef (level 1)Meeting registration - Welcome coffee

Welcome introduction

Amphithéâtre Salle Royale (level 2)

Hans Yssel and Lydia Campos

Cytokines and immune regulation

Amphithéâtre Salle Royale (level 2)

Chairs: Hans Yssel (Paris) and Frank Antonicelli (Reims)

• Jean-Philippe Girard (Toulouse): Interleukin-33 in health and disease
• Cem Gabay (Switzerland): The role of the IL-1 cytokine family members IL-36 and IL-18 in inflammatory responses
• David Artis (United States): Immune regulation at barrier surfaces

Grande Nef (level 1)Coffee break - Visit of exhibition - Poster session

Host-Pathogen interaction

Amphithéâtre Salle Royale (level 2)

Chairs: Olivier Neyrolles (Toulouse) and François Trottein (Lille)

• Luis Quintana-Murci (Paris): The genetic and evolutionary determinants of population variation in immune response regulation
• Andrea Cooper (United Kingdom): Manipulating immunity - learning lessons from mycobacterium tuberculosis

Selected short oral presentations

• Stéphane Isnard (Paris): HIV-1 and HIV-2 induce Interferon-λ production by Plasmacytoid Dendritic Cells
• Jérôme Estaquier (Paris): Exhausted CD8 T cells during visceral leishmaniasis in rhesus macaques
• Étienne Meunier (Toulouse): Localization of Pseudomonas dictates divergent NAIP5-NLRC4 inflammasome- induced host responses

Transplantation (SFI-SFHI)

Salle 1-2 (level 2)

Chairs: Jean-Luc Taupin (Paris) and Myriam Labalette (Lille)

• Walter Reith (Switzerland): Expression, function and mechanism of action of BTN2A2, a new costimulatory molecule coregulated with MHC class II expression
• Nicolas Degauque (Nantes): Molecular basis of T lymphocyte alloreactivity

Selected short oral presentations

• Vincent Guichard (Paris): Calcium-mediated shaping of naive CD4 T cell phenotype and function
• Aurélie Sannier (Paris): Thymic function is a major determinant of antibody-mediated alloimmune rejection onset in heart transplantation
• Eros Marin (Nantes): Human tolerogenic dendritic cells regulate immune response through lactate synthesis and regulatory T cell induction

Stem cells

Salle 3-4 (level 2)

Chairs: Lydia Campos (Saint-Étienne) and Claudine Schiff (Marseille)

• Gerrit Schuurhuis (The Netherlands): The role of stem cells in measurable residual disease (MRD) detection in acute myeloid leukemia
• Dominique Bonnet (United Kingdom): Heterogeneity of the human haematopoietic stem cell compartment

Selected short oral presentations

• Léa Aubert (Reims): Haemostatic medical device mimicking stem cells niche for cell therapy
• Tiphanie Picot (Saint-Étienne): Embryonic Stem Cells Antigens (ESCA) expression in acute myeloid leukemia cells

Plateforme Cytométrie

Amphithéâtre Salle Clovis (level 2)

Modératrices : Sandra Audonnet (Reims) et Muriel Andrieu (Paris)

• Philippe Poncelet (Marseille) : Détection, caractérisation et comptage des particules sub-microniques en cytométrie : progrès récents et questions d’actualité
• Benoit Vingert (Paris) : Étude des caractéristiques phénotypiques et fonctionnelles des microparticules sanguines

Communications orales courtes sélectionnées

• Anne-Laure Iscache (Toulouse) : Développement d’une base de panels d’anticorps optimisés pour la cytométrie à partir des OMIPs publiés
• Pierre Grenot (Marseille) : Évaluation des caractéristiques techniques et applications multi-couleurs à haut contenu d’information sur un nouvel analyseurs 6-Lasers, 21-Couleurs : le CytoFLEX LX
• Thierry Idziorek (Lille) : Cytométrie spectrale & Drug screening : étude pharmacologique du récepteur P2X₇

Espace Le Millésime (level 1)Lunch

Grande Nef (level 1)Coffee - Visit of exhibition - Poster session

Neutrophil Club

Salle 1-2 (level 2)

Chairs: Véronique Witko-Sarsat (Paris) and Marco Cassatella (Italy)

• Tobias Dallenga (Germany): nhibition of neutrophil necrosis controls Mycobacterium tuberculosis growth after removal by macrophages
• Coraline Radermecker (Belgium): Release of Neutrophils Extracellular Traps as a main trigger for asthma onset
• Loic Rolas (United Kingdom): Aged Vasculature Supports Enhanced and Aberrant Neutrophil-Vessel Wall Interactions in vivo
• Sokchea Khou (Valbonne): Tumor-associated neutrophils during the course of cutaneous carcinogenesis
• Sarra Seninet (Bobigny): Neutrophil extracellular traps are both pro-and anti-inflammatory via mechanisms involving the C1q complement protein and the LL-37 anti-microbial peptide
• Giuseppina Caligiuri (Paris): The ITIM receptor CD31 plays a dual and critical role in neutrophil transmigration
• Diego Gómez (Spain): Identification of PSGL-1-driven signals that control intravascular neutrophil behavior and drive vascular injury
• Pacôme Lecot (Lyon): Toward a novel classification of pro-tumor neutrophils based on density, maturity and lipid metabolism –associated genes

ASSIM General Assembly

Salle 3-4 (level 2)

Industry Symposium

Amphithéâtre Salle Royale (level 2)

Chairs: Julie Cazareth (Valbonne) and Ivana Haluskova Balter (Lyon)

• Ex Vivo Assessment of Immune Cell Function. New Tools, Applications and Perspectives
  Miloud Tewfik - Beckman Coulter (France)
• Cell Counting and Image Cytometry
  Pierre-Oliver de Franco - ChemoMetec (Denmark)
• Multicolor analysis on the ZE-5 Cell Analyzer
  Laurence Talbot - Bio-Rad (France)
• Commited to Enabling Superior Multicolor Flow Cytometry for Enhanced
  Complex Immunophenotyping
  Carsten Wiethe - BioLegend (UK)
• Analyse et tri de grandes particules
  Rico Bongaarts - Union Biometrica (USA)

• Preparing for the new age of immunotherapy; Use of Plasma Cell,
  VS38c at diagnosis, MRD and for patients undergoing
  Daratumumab treatment for Multiple Myeloma (MM)
  Jesper Kühnau (Denmark) - Agilent Technologies France - Dako
• IncuCyte® technology : Time-lapse Imaging around the clock
  Jean-Baptiste Penigault - Essen Bioscience (UK)
• Single cell transcriptomics and single cell full-length sequencing of paired
  expressed V(D)J. From 100s to millions of cells
  Mickael Ploquin - 10x Genomics (USA)
• Specific antibodies : the best way to obtain it
  Philippe Sommer - ProteoGenix (France)
• Cell separation and flow cytometry analysis StraightFrom™ blood!
  Shahul Mouhamad, Nicolas Dumoitier - Miltenyi Biotec (France)

Neutrophils

Amphithéâtre Salle Royale (level 2)

Chairs: Mauro Perretti (United Kingdom) and Jamel el Benna (Paris)

• Mauro Perretti (United Kingdom): Resolution pharmacology - Harnessing endogenous pathways to terminate inflammation and promote tissue repair
• Mia Phillipson (Sweden): Neutrophils and angiogenesis
• Leo Koenderman (The Netherlands): How neutrophils shape adaptive immune responses

Prix Jeunes Cytométristes

Amphithéâtre Salle Clovis (level 2)

Modérateurs : Marielle Bouix (Thiverval-Grignon) et Bouchaib Lamkhioued (Reims)

• Morgane Gossez (Lyon) : Les lymphocytes B inhibent la prolifération lymphocytaire T et sur-expriment les checkpoints inhibiteurs PD-1 et PD-L1 au cours du choc septique
• Élise Bordet (Jouy-en-Josas) : Identification des macrophages et lymphocytes B du ganglion de porc et interaction avec le virus SDRPv
• Aurélien Corneau (Paris) : Caractérisation en cytométrie en masse multiparamétrique des lymphocytes T CD4 ex-vivo producteurs de VIH pendant la rechute du virus après une immunisation thérapeutique
• Théo Loustaud (Marseille) : Multiplexage et analyse semi-supervisée pour la titration massive de réactifs de cytométrie en flux

Grande Nef (level 1)Coffee break - Visit of exhibition - Poster session

Myeloid cells

Amphithéâtre Salle Royale (level 2)

Chairs: Sylvie Chollet-Martin (Paris) and Régis Josien (Nantes)

• Michael Sieweke (Marseille): Self renewal mechanisms of differentiated macrophages
• Patrizia Scapini (Italy): Neutrophils in the saga of myeloid cells plasticity

Selected short oral presentations

• Alexandre Boissonnas (Paris): Regulation and function of monocyte margination in inflammation
• Orianne Wagner-Ballon (Créteil): Accumulation of classical monocytes defines a subgroup of MDS that frequently evolve into CMML
• Sandrine Delbosc (Paris): Porphyromonas gingivalis impacts on macrophages phenotype transition through a gingipaïn-dependent mechanism

Anti-viral immunity and therapy

Salle 1-2 (level 2)

Chairs: Delphine Sauce (Paris) and Jean-Daniel Lelièvre (Paris)

• René Van Lier (The Netherlands): Growing up with (herpes) viruses
• Dirk Busch (Germany): Adoptive T cell therapy of infections upon allogeneic stem cell transplantation

Selected short oral presentations

• Mireia Pelegrin (Montpellier): Key immunomodulatory role of neutrophils in the induction of protective immunity by antiviral monoclonal antibodies
• Raphaël Jeger-Madiot (Paris): T follicular helper cells differentiation during HIV infection
• Laurence Weiss (Paris): Preservation of IL-17 producing γδ T cells and their role in the control of immune activation in HIV controllers

T Lymphocytes

Amphithéâtre Salle Clovis (level 2)

Chairs: Muriel Andrieu (Paris) and Julie Déchanet-Merville (Bordeaux)

• Alexander Scheffold (Germany): The response of human regulatory T cells to environmental antigens
• Marie Malissen (Marseille): Interactomics and structure-function analysis of the RLTPR protein underpin its essential role for costimulation via CD28 in mouse and human T cells

Selected short oral presentations

• Bruno Martin (Paris): Macrophages induce long-term trapping of γδ T cells with innate-like properties within secondary lymphoid organs in the steady state
• Étienne Humblin (Dijon): IRF8-dependent molecular complexes control the Th9 transcriptional program
• François Santinon (Bobigny): TNFR2⁺ regulatory T cells subpopulations are highly suppressive and are increased on anti-TNF treatment in rheaumtoid arthrtis patients

Maladie résiduelle leucémique

Salle 3-4 (level 2)

Modérateurs : Bernard Châtelain (Yvoir, Belgique) et Michel Ticchioni (Nice)

• Marie-Christine Béné (Nantes) : Maladie résiduelle : quand, comment, pourquoi ?
• Vahid Asnafi (Paris) : Évaluation de la MRD par CMF dans les LAL
• Adriana Plesa (Pierre-Bénite) et Christophe Roumier (Lille) : Suivi de la MRD des essais de l’intergroupe français de LAM en cytométrie en flux multiparamétrique : intérêt d’une double approche LAIP et LSC, aspect méthodologique de la mise en place d’un suivi multicentrique

Communications orales courtes sélectionnées

• Tiphanie Picot (Saint-Priest-en-Jarez) : Expression des antigènes embryonnaires dans les cellules du compartiment CD34⁺CD38^- leucémique : utilité pour le suivi de la maladie résiduelle
• Malika El Ouaaliti (Belgium) : Contribution de la cytométrie en flux dans le diagnostic du syndrome myélodysplasique : sensibilité et spécificité des anomalies immuno-phénotypiques observées sur les cellules hématopoïétiques des patients
• Marie Loosveld (Marseille) : Détection de la maladie résiduelle dans les LAL-B par l’utilisation d’un tube “Duraclone”
• Isabelle Arnoux (Marseille) : Mesure de la ploïdie des LALB : un test rapide- Cell Cycle Kit

Grande Nef (level 1)Welcome cocktail - Poster session