SFI-AFC 2022

Rhodes - Level 2 Welcome coffee

Room Gallieni 5 - Level 2

Core facility session: ‘Analysis of microparticules’

Chairs: Muriel Andrieu (Paris) & Agnès Loubat (Nice)

• Agnès Loubat (Nice): Purification de granules subcellulaires
• Pierre-Henri Commere (Paris): Novel method for Extracellular vesicules and Virus Analysis by NanoCytometry

Selected short oral presentation

• Alia Bahri (Nice): Environmental stress control RNA granule formation and content in C.elegans

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Auditorium Athéna - Level 2

Immunometabolism

Chairs: Stoyan Ivanov (Nice) & David Sancho (Spain)

• Stoyan Ivanov (Nice): Brown adipose tissue myeloid cell diversity and functions
• Massimiliano Mazzone (Leuven, Belgium): Harnessing tumor metabolism to overcome immunosuppression: A novel way to enhance the success of cancer immunotherapy

Selected short oral presentations

• Laurent L’Homme (Lille): Macrophage infiltration and hepatocyte stress regulate GDF-15 in obesity, type 2 diabetes and NASH
• Marine Monnier (Angers): Impact of the ketone body acetoacetate on the functional polarization of human macrophages
• Paulina Garcia Gonzalez (Marseille): Single-cell profiling of metabolic states coupled to epigenetic heterogeneity in immune cells

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Room Rhodes 9 - Level 2

Omics analysis

Chairs: Félix Hartmann (Heidelberg, Germany) & Samuel Granjeaud (Marseille)

• Felix Hartmann (Heidelberg, Germany): Beyond phenotype - Quantifying cellular metabolism in single cells and tissues through multiplexed imaging
• Martin Guilliams (Ghent, Belgium): Analysis of spatial multi-omics data

Selected short oral presentations

• Nathan Foulquier (Brest): Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases
• Cristian Iperi (Brest): Role of metabolism in the dysfunction of B lymphocytes in Systemic Lupus Erythematosus

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Room Risso 6 - Level 2

Transplantation : Nouvelles immunothérapies

Modératrices : Sophie Candon (Mont-Saint-Aignan) & Alice Koenig (Lyon)

• Julien Zuber (Paris) : CAR-engineered regulatory T cells in transplantation: where do we stand, where do we go?
• Gilles Blancho (Nantes) : Thérapies ciblées

Présentations orales sélectionnées

• Yves Renaudineau (Toulouse): The oxygen carrier M101 alleviates complement activation, which may be beneficial for donor organ preservation
• Emilie Lebraud (Paris): Gaining insights into the origin and pathophysiological effects of non-HLA antibodies using a newly developed universal endothelial crossmatch assay
• Tifanie Blein (Paris): Use of TCR-deficient CAR-Tregs in combination with anti-CD3 monoclonal antibodies for inducing durable tolerance

Rhodes - Level 2 Coffee break - Visit of exhibition

Room Gallieni 5 - Level 2

Oceanobiology

Chairs: Frédéric Larbret (Nice) & Gérald Grégori (Marseille)

• Benyamin Rosental (Beer-Sheva, Israel): Unique evolutionary approaches of FACS in non-classical model organisms, reveal applications and discoveries of immunity and stem cell transplantation
• Gérald Grégori (Marseille): The waltz of marine plankton revealed by automated flow cytometry

Selected short oral presentation

• Mélanie Billaud (Monaco): Cell type identification in the different tissues of Exaiptasia pallida during Vibrio parahaemolyticus infection by histology and spectral cytometry techniques

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Room Risso 6 - Level 2

Immune Ageing

Chairs: Julien Cherfils-Vicini (Nice) & Anne Astier (Toulouse)

• Delphine Sauce (Paris): Hip fracture as a model of acute stress
• Arne Akbar (Londres, Uk): Strategies for enhancing immunity for ageing

Selected short oral presentations

• Jérémy Santamaria (Marseille): RANKL-mediated thymic rejuvenation improves peripheral immunity during aging
• Özmen Cobanoglu (Lille): Targeting senescent cells for imroving immune responses to vaccination in aged mice

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Auditorium Athéna - Level 2

Cancer immunology

Chairs: Véronique Braud (Valbonne) & Jacques Nunès (Marseille)

• Fabienne Anjuère (Valbonne): Comprehensive characterization of the tumor microenvironment of cutaneous squamous cell carcinomas
• Bertrand Dubois (Lyon): Disentangling the heterogeneity of antibody producing cells and its clinical impact in breast and ovarian cancers

Selected short oral presentations

• Pierre-Louis Bernard (Marseille): Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity
• Lionel Le Bourhis (Paris): Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition

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Room Rhodes 9 - Level 2

Auto-immunité, allergies et environnement

Modérateurs : Barbara Seitz-polski (Nice) &
Jean-François Nicolas (Lyon)

• Renato Monteiro (Paris): Microbiote et maladies auto-immunes : l’exemple de la néphropathie à IgA
• Valérie Siroux (Grenoble): Environmental epidemiology, exposome, asthma and allergy

Présentations orales sélectionnées

• Mahmoud Tarayrah (Paris): Smad7 dictates T-cell resistance to TGF-β and development of type 1 diabetes
• Maxime Teisseyre (Nice): Impact of Pollution on the Pathophysiology of Membranous Nephropathy
• Sophie Lalevée (Créteil): IL-33: amplifying cytotoxicity in epidermal necrolysis?

Auditorium Athéna - Level 2Industry talk: Data analysis

Chairs: Pierre Grenot (Strasbourg) & Aude Magerus (Paris)

• OMIQ
  OMIQ: Modern Software for Cellular Analysis
  Christopher Ciccolella (OMIQ, Inc.)

• Metafora
  Live demo of Metaflow an innovative tool for multidimensional data analysis
  Kamila Czechowska (Metafora Biosystems)

• Tercen Data Analytics
  Tercen: high-dimensional flow cytometry data analysis made easy
  Alexandre Gouy (Tercen)

• Beckman Coulter Life Sciences
  Cytobank platform Version 10: Say goodbye to manual gating
  Antoine Fouillet (Beckman Coulter Life Sciences)

Rhodes - Level 2 Lunch

Coffee - Visit of exhibition - Posters

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Room Risso 6 - Level 2ASSIM General Assembly

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Looking for an academic research position? Come and discuss with qualified colleagues!

Room Risso 8 - Level 2

Room Gallieni 5 - Level 2

3C Club

Chairs: Samuel Granjeaud (Marseille) & Alexia Alfaro (Villejuif)

• Anne-Laure Iscache (Toulouse): Good Practices in pre-processing data: focus on three automatic algorithms ‘flowClean’, ‘FlowAI’ and ‘flowCut’
• Annelies Emmaneel (Belgium): Why and how should we use quality control tools for cytometry data?
• Table ronde : Retours d’expérience en analyse, besoins à automatiser...

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Auditorium Athéna - Level 2

T cells

Chairs: Loredana Saveanu (Paris) & Abdelhadi Saoudi (Toulouse)

• Julien Marie (Lyon): A New Effector T cell Subset Leading to Cancer
• Magali Irla (Marseille): Lymphotoxin, a novel immune checkpoint of Treg suppressive activity

Selected short oral presentations

• Romain Roncagalli (Marseille): Analysis of the molecular mechanisms encoding TCR ligand discrimination
• Romain Peroceschi (Toulouse): The transcription factor Eomes controls regulatory T cell suppressive functions and plasticity
• Emilie Barsac (Tours): MAIT cells in Streptococcus pneumoniae pneumonia: Activation, functions and therapeutic opportunities?

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Room Risso 6 - Level 2

Extracellular vesicules

Chairs: Lorena Martin-Jaular (Paris) & Stéphane Robert (Marseille)

• Lorena Martin-Jaular (Paris): EV heterogeneity and functional consequences
• Guillaume Van Niel (Paris): Basic lessons and therapeutic applications of live imaging of extracellular vesicles in vivo
• Coralie Guerin (Paris): Extracellular Vesicle Surface Signatures in hospitalized COVID-19 Patients

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Room Rhodes 9 - Level 2

Analyses multiparamétriques de l’immunité antitumorale et anti-infectieuse

Modérateurs : Guislaine Carcelain (Paris) & Jean-Daniel Lelievre (Paris)

• Joshua Waterfall (Paris) : Heterogeneity and ontogeny of tumor infiltrating CD4+ T cells in NSCLC
• Rodolphe Thiébaut (Bordeaux) : Analysis of gene expression data applied to SARS-COV2 infected patients

Présentations orales sélectionnées

• Luciana Petti (Valbonne): The TNC extracellular matrix protein modulates spatial distribution and phenotypes of tumor-associated myeloid cell populations in oral squamous cell carcinoma
• Claude Capron (Boulogne): Combined coagulation and inflammation markers as predictors of death and venous thrombo-embolism in COVID-19

Auditorium Athéna - Level 2Keynote lecture (Pierre Grabar Lecture)

Chair: Renato Monteiro (Paris)

• Gwendalyn Randolph (Saint-Louis, USA): Immunity in the mesentery and visceral cavity - translational studies between mouse and human

Auditorium Athéna - Level 2Prize awards - Conclusion