FSSCR 2022

Galerie Herrade de Landsberg (Level 1) Meeting registration - Welcome coffee

Espace Schuman (Level 1)Welcome introduction

• John De Vos, President of the FSSCR, Brigitte Malgrange, President of the BeSSCR and Vincent Flacher, President of the GDR Organoïdes

Espace Schuman (Level 1)Session 1 - Disease models

Chairs: Jean-Noël Freund & Claire Rougeule

• Modelling Early Human Embryogenesis with Naive Pluripotent Stem Cells
  Vincent Pasque (University of Leuven, Louvain, Belgique)

• Deconstructing the principles of cellular hierarchy in brain tumors
  Cédric Maurange (Marseille)

• General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions
  Jean-Noël Freund (Inserm, Strasbourg)

Selected Short talk

• A stochastic lineage tracking model to unravel the function of the thyroid hormone receptor TRα1 in the heterogeneity and hierarchy of colorectal cancer cells
  Léo Claret (Inserm, Strasbourg)

---

Give voice to the industrials

• StemCell Technologies
  Optimization of 2D and 3D Large-Scale Production Methods for the Expansion of High-Quality Human Pluripotent Stem Cells
  Camille Tempier Lemey (StemCell Technologies)

Lunch

Galerie Herrade de Landsberg (Level 1) Coffee - Visit of exhibition - Posters

Espace Schuman (Level 1)Session 2 - Organoids

Chairs: Céline Cougoule & Vincent Flacher

• Human bronchial organoids unveil druggable pathways against Mycobacterium abscessus infection in cystic fibrosis
  Céline Cougoule (IPBS, Toulouse)

• Cerebral organoids derived from progeroid, neurodegenerative, and highly heterogeneous Cockayne syndrome patients
  Miria Ricchetti (Institut Pasteur, Paris)

Selected Short talks

• Generation of apical-out airway organoids and their applications in viral infection and antiviral drug screening
  Salvatore Simmini (StemCell Technologies, Cambridge)

• Full field-OCT imaging for intestinal organoid characterization and function
  Killian Hillion (Inserm, Nantes)

---

Give voice to the industrials

• VectorBuilder
  A short introduction of VectorBuilder
  Auguste Attenot (VectorBuilder)

• Advanced Instruments
  Development of a highly efficient, documented workflow for making clonal cell banks of gene-edited iPSCs
  Saci Iken (Advanced Instruments)

Galerie Herrade de Landsberg (Level 1) Coffee break - Visit of exhibition - Posters

Espace Schuman (Level 1)Session 3 - Stem cells, regeneration and evolution

Chairs: Mathilde Paris & Charles Durand

• Stem cell decision making in Hydra as an interplay between the animal host and a multitude of beneficial microbes
  Thomas Bosch (University of Kiel, Allemagne)

• Crustacean leg regeneration restores complex microanatomy and cell diversity
  Mathilde Paris (IGFL, Lyon)

Selected Short talks

• Optimization of the differentiation of pluripotent stem cells to intervertebral disc progenitor cells based on single-cell transcriptomics
  Julie Warin (Nantes Université, Nantes)

• In vitro cell competition between pluripotent stem cell lines predicts their ability to make chimeric embryos in primates
  Irène Aksoy (Inserm, Lyon)

Espace Schuman (Level 1)Session 4 - Ethics

Chair: Pierre Savatier

• Enjeux éthiques des modèles embryonnaires
  Hervé Chneiweiss (Paris)

Round table

• Hervé Chneiweiss, Jean-François Guérin, Karen Sermon, Nelly Frydman and Pierre Savatier

Selected Flash talks

• FluidFM^® technology enables monoclonal, specific and efficient human iPSCs CRISPR/Cas9 engineering
  Constance Ciaudo Beyer (Cytosurge AG, Glattbrugg, Switzerland)
• A relevant cellular model to study imprinting disorders: dental pulp stem cells
  Eloïse Giabicani (Sorbonne Université, Paris)
• Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes
  Alice Jouneau (BREED, INRAe, Jouy-en-Josas)
• Synergistic effect of ascorbic acid and hypoxia allows the maintenance of imprinted regions methylation pattern in human induced pluripotent stem cells
  Céline Selenou (Sorbonne Université, Paris)
• Greb1l plays a vital role during the epiblast maturation of mouse embryos
  Lahiru-Chamara Weerasinghe-Arachchige (Université Côte d’Azur, Nice)

Galerie Herrade de Landsberg (Level 1) Welcome Cocktail

Posters & Networking session

Espace Schuman (Level 1)Session 5 - Regenerative medicine and clinical trials

Chairs: Agnete Kirkeby & Cécile Martinat

• Bringing an hESC-derived dopamine cell product for Parkinson’s Disease towards clinical trial
  Agnete Kirkeby (University of Copenhagen, Denmark)

• Extracellular vesicles for cardiac repair and regeneration
  Philippe Ménasché (Hôpital Européen, Paris)

Selected Short talks

• Pluripotent stem cell-derived cardiomyocytes to study mitochondrial dysfunctions induced by a heterozygous DES mutation
  Pierre Joanne (IBPS, Paris)

• Molecular mechanisms underlying the production of hematopoietic stem cells from human-induced pluripotent stem cells
  Olivier Piau (IBPS, Paris)

---

Give voice to the industrials

• Stem Genomics
  Why you should routinely test the genomic integrity of your cell lines?
  Juline Vincent (Stem Genomics)

Galerie Herrade de Landsberg (Level 1) Coffee break - Visit of exhibition - Posters

Espace Schuman (Level 1)Session 6 - Bioengineering

Chairs: Xavier Gidrol & Frank Yates

• Neural regulation of stem and progenitor cells in the developing gut
  Maxime Mahé (Inserm, Nantes)

• An automated microfluidic platform integrating vascularized organoids on chip
  Xavier Gidrol (BIOMICS, Grenoble)

Selected Short talks

• Bioengineering the aged neural stem cell niche with 3D organ-on-chips
  Lida Katsimpardi (Instituts Necker and Pasteur, Paris)

• An innervated and immunocompetent human skin model to study arboviral cutaneous infection
  Benjamin Voisin (CNRS, Strasbourg)

Espace Schuman (Level 1)Session 7 - Niche stem cells

Chairs: Shahragim Tajbakhsh & Michelina Plateroti

• Role of somite-derived endothelial cells in hematopoietic stem cell emergence
  David Traver (University of California, San Diego, USA)

• Skeletal muscle stem and niche cell perturbations in pathologies
  Shahragim Tajbakhsh (Institut Pasteur, Paris)

Selected Short talks

• Single-cell transcriptomics reveals age-resistant maintenance of cell identities and stem cell compartments in long-lived naked mole-rats skin
  Aleksandra Savina (Institut Cochin, Paris)

• Assessing human stem cell models of human peri-implantation development
  Constance Onfray (CRTI, Nantes)

Lunch

Galerie Herrade de Landsberg (Level 1) Coffee - Visit of exhibition - Posters

Session 8 - Self organisation and genetic integrity of pluripotent stem cells

Espace Schuman (Level 1)

Chairs: Claire Chazaud & Nathalie Lefort

• Loosing pluripotency: how chromosomal abnormalities are changing the differentiation capacity of hPSC
  Claudia Spits (VUB, Bruxelles, Belgique)

• Cell Lineage Differentiation in the Blastocyst: The emergence of the Pluripotent Epiblast
  Claire Chazaud (Clermont-Ferrand)

Espace Schuman (Level 1)Concluding remarks & Prizes