Webinar EBCnet Forum 2021

Opening of the 3^rd EBCNet Forum

Thierry Defrance and Hans-Martin Jäck

Session #1. B cell memory/B cell subsets

Talk participants

Chairs: Michel Cogné & Marc Seifert

• Most isotype switched memory B cells reside in bone marrow or spleen
  Marta Ferreira-Gomes (Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association, Berlin, Germany)

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• Human memory B cell dynamics in blood and spleen change with age
  Artur Kibler (Institute of Cell Biology, University of Duisburg-Essen, Essen, Germany)

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• Diversity of memory B cells repertoire cope with SARS-CoV2 variants after mRNA vaccination in naïve and recovered individuals
  Matthieu Mahévas (Institut Necker Enfants Malades (INEM), INSERM U1151/CNRS UMS 8253, Université de Paris, Paris, France)

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• Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG
  Stephan Winklmeier (Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, Munich, Germany)

Sponsor - Miltenyi Biotec

• SARS-CoV-2 specific B cells and antibodies Analysis by Miltenyi Biotec
  Shahul Mouhamad - Miltenyi Biotec

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Break

Session #1 (continued). B cell memory/B cell subsets

Talk participants

Chairs: Pierre Bruhns & Deborah Dunn-Walters

• VAST: a novel and versatile vaccination platform that induces robust and durable antibody responses
  Paraskevi Vlachou (D150, German Cancer Research Center (DKFZ), Heidelberg, Germany)

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• Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways
  Alexander Stewart (School of Biosciences and Medicine, University of Surrey, Guildford, UK)

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• T-bet+ B cells infiltrating the human brain: from peripheral induction to local effector function
  Marvin M. van Luijn (Department of Immunology, MS Center ErasMS, Erasmus MC, Rotterdam, The Netherlands)

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• Phenotypic and functional division of human Bregs in CD45^lo and CD45^hi B cells and their dependence on Btk and mTOR
  Vassilios Lougaris (Pediatrics Clinic and Institute of Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST - Spedali Civili of Brescia, Brescia, Italy)

Sponsor - Stemcell

• Tools for B cell Research
  Graeme Milton - Senior European Market Development Manager, Immunology

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Lunch

Session #2. B cell development/B cell neoplasia

Talk participants

Chairs: Marta Rizzi & Thierry Defrance

• Transcription factor networks coordinate transcriptional priming and cellular expansion in early B-cell development
  Mikael Sigvardsson (Division of Molecular Hematology, Lund University, Lund, Sweden)

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• IL-7R signalling activates widespread V_H and D_H gene usage to drive antibody diversity in bone marrow B cells
  Anne Corcoran (Lymphocyte Signalling and Development Programme, Babraham Institute, Cambridge, UK)

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• Tracking neonatal B cell function in the adult gut
  Joan Yuan (Division for Molecular Hematology, Lund Stem Cell Center, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Lund, Sweden)

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• Siglec-G controls the severity of Chronic Lymphocytic B-cell Leukemia
  Lars Nitschke (Division of Genetics, Department of Biology, University of Erlangen, Erlangen, Germany)

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• Continuous MYD88 activation is associated with expansion and then transformation of IgM differentiating plasma cells
  Christelle Vincent-Fabert (UMR CNRS 7276/INSERM U1262 CRIBL. University of Limoges, and hematology Laboratory of Dupuytren Hospital University Center (CHU) of Limoges, France)

Sponsor - Cytek Biosciences

• How spectral flow could be the solution for your lab
  Juliette Desfrançois - Cytek Biosciences

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Break

Keynote lecture

• Memory B cells differentiation
  Dr Charlotte Viant (Laboratory of Molecular Immunology, The Rockefeller University, New York, USA)

EBCnet General assembly